Laffi undertook the pilgrimage in 1678-1679. His route was unusual: he travelled via Corsica, Tunis, Malta, Crete and Cyprus. Laffi had already undertaken three pilgrimages to Santiago di Compostela, in 1666, 1670 and 1673, and his account of these pilgrimages was published in 1673 as Viaggio in Ponente à San Giacomo di Galitia.
Viaggio In Levante Al Santo Sepolcro Di N. S. G. Cristo, Et altri Luoghi di Terra Santa, Di D. Domenico Laffi Bolognese. In Bologna, per Costantino Pisarri, sotto le Scuole, all’Ins. di S. Michele. 1708. Con lic. de’Superiori.